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The skin forms the outer barrier of the body. As the largest organ, the skin harbors its own defense mechanisms and immune cells. Due to the constant contact with pathogens and environmental hazards, skin diseases are among the most common diseases.
To meet the standard of high quality patient care we continuously study the causes of diseases and new therapy options. Since the appointment of Prof. Kamran Ghoreschi as Director of the Department of Dermatology, Venereology and Allergology in 2018, our research group - AG Molecular Immunology Charité (MIC) – is part of the Charité - Universitätsmedizin Berlin.
The research group MIC
Our group focuses on the following topics
- Chronic inflammatory skin diseases (psoriasis, lichen planus, atopic dermatitis, acne inversa)
- Autoimmune skin diseases (bullous pemphigoid, pemphigus, lupus, scleroderma)
- Skin cancer (melanoma, squamous cell carcinoma, basal cell carcinoma and cutaneous lymphoma).
Our team consists of physicians and scientists. Our goal is to understand immunological and molecular pathomechanisms and to identify diagnostic and therapeutic approaches for the development of personalized medicine. Therefore, we investigate basic principles in vitro as well as in preclinical models and in translational clinical studies. One focus is the investigation of T cell responses and cytokine signals of the JAK/STAT signaling pathway.
In the field of immunooncology we characterize tumor-associated and tumor-independent immune cells during treatment with checkpoint inhibitors. Using next-generation sequencing we want to identify genetic biomarkers. By applying liquid biopsy we want to provide possibilities for therapy monitoring in patients with skin tumors.
Our routine laboratory methods include
- In vitro (2D, 3D) and in vivo models
- Histology and immunofluorescence
- RNA analyses (qPCR, RNA-Seq)
- NGS (Panel, WES and WGS)
- Protein analysis (Western Blot)
- Multiparametric analysis of cells (flow cytometry, CyTOF)